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Effect of a high-intensity interval training on serum microRNA levels in women with breast cancer undergoing hormone therapy. A single-blind randomized trial / Shaban Alizadeh in Annals of physical and rehabilitation medicine, Vol. 62 n° 5 (September 2019)
[article] Effect of a high-intensity interval training on serum microRNA levels in women with breast cancer undergoing hormone therapy. A single-blind randomized trial [texte imprimé] / Shaban Alizadeh, Auteur ; Amin Isanejad, Auteur ; Sanambar Sadighi, Auteur . - 2019 . - p. 329-335.
Langues : Anglais (eng) Français (fre)
in Annals of physical and rehabilitation medicine > Vol. 62 n° 5 (September 2019) . - p. 329-335
Catégories : PATHOLOGIE
Cancer , Glande mammaire [pathologie]
THÉRAPEUTIQUE
Hormonothérapie
MOTS OUTILS
RandomisationUtilisation du hasard dans la constitution d'un échantillon pour une étude ou une enquête.
Tags : microRNAs Breast cancer Hormone therapy Training Résumé : Background: The role of microRNAs (miRs) in hormone therapy (HT) is of keen interest in developing biomarkers and treatments for individuals with breast cancer. Although miRs are often moderate regulators under homeostatic conditions, their function is changed more in response to physical activity.
Objective: This single-blind randomized trial aimed to explore the effect of high-intensity interval training (HIIT) on serum levels of miRs in individuals with early-stage breast cancer undergoing HT.
Methods: Hormone receptor-positive women with breast cancer and healthy women were randomly assigned to a healthy control group (n =15), healthy group with HIIT (n =15), breast cancer group with HT (HT, n =26), and breast cancer group with HT and HIIT (HT+HIIT, n =26). The exercise groups underwent interval uphill walking training on a treadmill 3 times a week for 12weeks. At the end of the study, we analyzed changes in levels of cancer-related miRs (oncomiRs) and tumour suppressor miRs (TSmiRs) in response to the HT and HIIT.
Results: In women with breast cancer versus healthy controls, the expression of some oncomiRs was significantly increased — miR-21 (P <0.001), miR-155 (P =0.001), miR-221 (P =0.008), miR-27a (P <0.001), and miR-10b (P =0.007) — and that of some TSmiRs was significantly decreased — miR-206 (P =0.048), miR-145 (P =0.011), miR-143 (P =0.008), miR-9 (P =0.020), and let-7a (P =0.005). Moreover, HT considerably downregulated oncomiRs and upregulated TSmiRs. HIIT for 12weeks with HT significantly decreased the expression of the oncomiRs and significantly increased that of the TSmiRs as compared with HT alone.
Conclusions: HITT could amplify the decrease and/or increase in expression of miRs associated with HT in women with breast cancer. A prospective trial could determine whether the use of circulating miRs for monitoring treatment can be useful in therapy decisions.
En ligne : http://www.em-consulte.com/produit/rehab Permalink : https://ifm3r.centredoc.fr/index.php?lvl=notice_display&id=17347 [article]Checklists to manage Pain Induced by Exercise and Mobilization (PIEM) during physical therapy programs: PIEM checklists for practitioners and physiotherapists / Sophie Alami in Annals of physical and rehabilitation medicine, Vol. 58 n° 2 (April 2015)
[article] Checklists to manage Pain Induced by Exercise and Mobilization (PIEM) during physical therapy programs: PIEM checklists for practitioners and physiotherapists [texte imprimé] / Sophie Alami, Auteur ; Clémence Palazzo, Auteur ; Serge Poiraudeau, Auteur . - 2015 . - p. 66-73.
Langues : Anglais (eng) Français (fre)
in Annals of physical and rehabilitation medicine > Vol. 58 n° 2 (April 2015) . - p. 66-73
Catégories : SYMPTÔME
Douleur
PRATIQUE MÉDICALE
Rééducation fonctionnelleTags : Care-related pain Training Rehabilitation programs Physical therapy Physical medicine and rehabilitation Résumé : Objectives : Identify key informational and educational items (“messages”) to provide to physicians (general practitioners and specialists) and physiotherapists for the management of pain induced by exercise and mobilization (PIEM). Develop checklists to improve this management in daily practice.
Material and methods : The Delphi method for consensus-building was used to identify informational and educational messages for health professionals who deal with PIEM. Informed by the results of an extensive qualitative study, a panel of experts from 5 medical and paramedical disciplines concerned with PIEM and a representative of a patients’ association were interviewed individually and iteratively in order to obtain a single, convergent opinion.
Results : Delphi consultation helped to determine 9 areas corresponding to 54 key messages of information and education for doctors and physiotherapists who deal with PIEM. These messages relate to: defining, characterizing, identifying, and evaluating PIEM; identifying factors that may cause or increase this pain; informing the patient in order to avoid misinterpretation of PIEM; preventing and treating PIEM; and dealing with it during physical therapy sessions. The method also enabled us to develop 2 synthetic instruments (checklists) — 1 for physicians and 1 for physiotherapists — to help with the management of this pain.
Conclusion: Consulting a panel of experts comprising different categories of actors dealing with PIEM on the basis of a thorough qualitative diagnosis in order to identify messages for a training program makes it possible to harmonize programs with the expectations of patients and the problems encountered by professionals. The formulation of this program and the institutionalization of two checklists should enable health professionals to identify, qualify, and deal more effectively with PIEM.En ligne : http://www.em-consulte.com/produit/rehab Permalink : https://ifm3r.centredoc.fr/index.php?lvl=notice_display&id=12181 [article]