Institut Régional de Formation aux Métiers de Rééducation et de Réadaptation des Pays de la Loire.
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An update on the pathophysiology of osteoarthritis / Ali Mobasheri in Annals of physical and rehabilitation medicine, Vol. 59 n° 6 (December 2016)
[article] An update on the pathophysiology of osteoarthritis [texte imprimé] / Ali Mobasheri, Auteur ; Mark Batt, Auteur . - 2016 . - p. 333-339.
Langues : Anglais (eng) Français (fre)
in Annals of physical and rehabilitation medicine > Vol. 59 n° 6 (December 2016) . - p. 333-339
Catégories : PATHOLOGIE
INFORMATION & COMMUNICATION
Thesaurus Santé Publique
Articulation , Genou , Ligament , Rotule
Tags : Synovial joint Articular cartilage Synovium Osteoarthritis (OA) Pathophysiology Physical Activity Physical Rehabilitation Résumé : Introduction: Osteoarthritis (OA) is one of the most common forms of arthritis. There is accumulating evidence to suggest that OA is an inflammatory disease of the entire synovial joint and has multiple phenotypes. This presents the OA research community with new challenges and opportunities. The main challenge is to understand the root cause of the disease and identify differences and similarities between OA phenotypes. The key opportunity is the possibility of developing personalized and individualized prevention and treatment strategies for OA patients with different phenotypes of the disease. Indeed, it has been suggested that this is the era of personalized prevention for OA. The aim of this mini-review paper is to focus on the pathophysiological aspects of OA development and progression, review the current concepts and discuss the future of personalized medicine for OA.
Method: The PubMed/MEDLINE bibliographic database was searched using the keywords pathophysiology and osteoarthritis.
Results: The PubMed/MEDLINE search yielded more than 12,000 relevant papers. A selection of these papers is reviewed here.
Conclusion: There has been slow but steady progress in our understanding of the pathophysiology of OA over the last two decades. However, large gaps remain in our knowledge of OA pathogenesis and this impacts negatively on patients and drug development pipeline. In the absence of new pharmaceutical agents and disease modifying osteoarthritis drugs (DMOADs) it is clear that lifestyle modification and physical activity are important and may delay the need for surgical intervention.
En ligne : http://www.em-consulte.com/produit/rehab Permalink : [article]Joint contractures and acquired deforming hypertonia in older people: Which determinants? / Patrick Dehail in Annals of physical and rehabilitation medicine, Vol. 62 n° 6 (November 2019)
[article] Joint contractures and acquired deforming hypertonia in older people: Which determinants? [texte imprimé] / Patrick Dehail, Auteur ; Nathaly Gaudreault, Auteur ; Haodong Zhou, Auteur . - 2019 . - p. 435-441.
Langues : Anglais (eng) Français (fre)
in Annals of physical and rehabilitation medicine > Vol. 62 n° 6 (November 2019) . - p. 435-441
Catégories : PHYSIOLOGIE
PhysiopathologieÉtude du fonctionnement de l'organisme ou d'un organe lorsqu'il est troublé par la maladie
ÉtiologieÉtude des circonstances ayant entouré l'apparition d'une maladie, qu'elles l'aient favorisée ou non.
Tags : Contractures Aquired deforming hypertonia Etiological factors Pathophysiology Résumé : Joint contractures and acquired deforming hypertonia are frequent in dependent older people. The consequences of these conditions can be significant for activities of daily living as well as comfort and quality of life. They can also negatively affect the burden of care and care costs. However, etiological factors and pathophysiologic mechanisms remain only partly understood. As a result, preventive interventions and treatments focus entirely on controlling symptoms rather than the causes. Moreover, the effectiveness of these interventions remains to be validated. The purpose of this position paper is to present current data on etiological factors contributing to the development of joint contractures and acquired deforming hypertonia in older people. The pathophysiologic mechanisms of joint contractures in animal models are also presented. En ligne : http://www.em-consulte.com/produit/rehab Permalink : [article]